Source 1primary paper1998British Journal of Ophthalmology
Toolkit/macular volumetric quantification above a reference plane
macular volumetric quantification above a reference plane
Also known as: new technique for the assessment of macular thickening by volumetric quantification, volume above reference plane measurement
Taxonomy: Technique Branch / Method. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Macular volumetric quantification above a reference plane is an imaging-based assay implemented on the Heidelberg Retina Tomograph to measure macular tissue volume above a defined reference plane. It quantifies volume within 1 mm, 2 mm, and 3 mm diameter circles centered on the fovea and was reported to be reproducible in normal subjects.
Usefulness & Problems
Why this is useful
This method provides a standardized way to quantify macular volume from retinal imaging rather than relying only on qualitative assessment. The source literature suggests potential utility for identifying and quantifying diabetic macular oedema and for monitoring the effects of argon laser photocoagulation.
Problem solved
The assay addresses the problem of obtaining reproducible quantitative measurements of macular thickening from Heidelberg Retina Tomograph images. It operationalizes macular assessment by measuring volume above a reference plane in fixed fovea-centered regions of interest.
Taxonomy & Function
Primary hierarchy
Technique Branch
Method: A concrete measurement method used to characterize an engineered system.
Mechanisms
optical imaging-based volumetric quantificationoptical imaging-based volumetric quantificationreference-plane-based geometric volume measurementreference-plane-based geometric volume measurementstandardized region-of-interest quantificationTarget processes
recombinationInput: Light
Implementation Constraints
cofactor dependency: cofactor requirement unknownimplementation constraint: context specific validationimplementation constraint: spectral hardware requirementoperating role: sensorreadout: volume above reference planeregions: 1 mm, 2 mm, and 3 mm diameter circles
The method is performed on the Heidelberg Retina Tomograph and measures volume above a reference plane within 1 mm, 2 mm, and 3 mm diameter circles centered on the fovea. At each examination, the reference plane is adjusted to the lowest point of contour-line height variation. No additional details on construct design, cofactors, or non-ophthalmic implementation are provided in the supplied evidence.
Evidence is limited to a reproducibility study in normal subjects from a single cited publication. Measurement variability increased significantly as volumetric measurements increased, and the proposed applications to diabetic macular oedema and post-photocoagulation monitoring were presented as potential uses rather than direct validation.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
The standard deviation of volumetric measurements increased significantly as volumetric measurements increased.
Linear regression demonstrated a significant increase in SD as volumetric measurements increased (p = 0.003).
Section: abstract
p value 0.003
The standard deviation of volumetric measurements increased significantly as volumetric measurements increased.
Linear regression demonstrated a significant increase in SD as volumetric measurements increased (p = 0.003).
Section: abstract
p value 0.003
The standard deviation of volumetric measurements increased significantly as volumetric measurements increased.
Linear regression demonstrated a significant increase in SD as volumetric measurements increased (p = 0.003).
Section: abstract
p value 0.003
The standard deviation of volumetric measurements increased significantly as volumetric measurements increased.
Linear regression demonstrated a significant increase in SD as volumetric measurements increased (p = 0.003).
Section: abstract
p value 0.003
The standard deviation of volumetric measurements increased significantly as volumetric measurements increased.
Linear regression demonstrated a significant increase in SD as volumetric measurements increased (p = 0.003).
Section: abstract
p value 0.003
The macular volumetric method measured volume above a reference plane within 1 mm, 2 mm, and 3 mm diameter circles centered on the fovea, with the reference plane adjusted to the lowest point of contour-line height variation at each examination.
The volumes above the reference plane bound by a 1 mm, 2 mm, and 3 mm diameter circle were measured. The reference plane was adjusted to the lowest point of the height variation of the contour line at each examination.
Section: abstract
The macular volumetric method measured volume above a reference plane within 1 mm, 2 mm, and 3 mm diameter circles centered on the fovea, with the reference plane adjusted to the lowest point of contour-line height variation at each examination.
The volumes above the reference plane bound by a 1 mm, 2 mm, and 3 mm diameter circle were measured. The reference plane was adjusted to the lowest point of the height variation of the contour line at each examination.
Section: abstract
The macular volumetric method measured volume above a reference plane within 1 mm, 2 mm, and 3 mm diameter circles centered on the fovea, with the reference plane adjusted to the lowest point of contour-line height variation at each examination.
The volumes above the reference plane bound by a 1 mm, 2 mm, and 3 mm diameter circle were measured. The reference plane was adjusted to the lowest point of the height variation of the contour line at each examination.
Section: abstract
The macular volumetric method measured volume above a reference plane within 1 mm, 2 mm, and 3 mm diameter circles centered on the fovea, with the reference plane adjusted to the lowest point of contour-line height variation at each examination.
The volumes above the reference plane bound by a 1 mm, 2 mm, and 3 mm diameter circle were measured. The reference plane was adjusted to the lowest point of the height variation of the contour line at each examination.
Section: abstract
The macular volumetric method measured volume above a reference plane within 1 mm, 2 mm, and 3 mm diameter circles centered on the fovea, with the reference plane adjusted to the lowest point of contour-line height variation at each examination.
The volumes above the reference plane bound by a 1 mm, 2 mm, and 3 mm diameter circle were measured. The reference plane was adjusted to the lowest point of the height variation of the contour line at each examination.
Section: abstract
Age did not significantly affect the standard deviation of volumetric measurements, and volumetric measurements did not differ significantly across ages for the 1 mm, 2 mm, and 3 mm circles.
Age did not significantly affect the SD of volumetric measurements (p = 0.797). The authors found no significant differences in volumetric measurements across all ages for all three circles (p = 0.314, p = 0.471, p = 0.267).
Section: abstract
p value 0.797p value 0.314p value 0.471p value 0.267
Age did not significantly affect the standard deviation of volumetric measurements, and volumetric measurements did not differ significantly across ages for the 1 mm, 2 mm, and 3 mm circles.
Age did not significantly affect the SD of volumetric measurements (p = 0.797). The authors found no significant differences in volumetric measurements across all ages for all three circles (p = 0.314, p = 0.471, p = 0.267).
Section: abstract
p value 0.797p value 0.314p value 0.471p value 0.267
Age did not significantly affect the standard deviation of volumetric measurements, and volumetric measurements did not differ significantly across ages for the 1 mm, 2 mm, and 3 mm circles.
Age did not significantly affect the SD of volumetric measurements (p = 0.797). The authors found no significant differences in volumetric measurements across all ages for all three circles (p = 0.314, p = 0.471, p = 0.267).
Section: abstract
p value 0.797p value 0.314p value 0.471p value 0.267
Age did not significantly affect the standard deviation of volumetric measurements, and volumetric measurements did not differ significantly across ages for the 1 mm, 2 mm, and 3 mm circles.
Age did not significantly affect the SD of volumetric measurements (p = 0.797). The authors found no significant differences in volumetric measurements across all ages for all three circles (p = 0.314, p = 0.471, p = 0.267).
Section: abstract
p value 0.797p value 0.314p value 0.471p value 0.267
Age did not significantly affect the standard deviation of volumetric measurements, and volumetric measurements did not differ significantly across ages for the 1 mm, 2 mm, and 3 mm circles.
Age did not significantly affect the SD of volumetric measurements (p = 0.797). The authors found no significant differences in volumetric measurements across all ages for all three circles (p = 0.314, p = 0.471, p = 0.267).
Section: abstract
p value 0.797p value 0.314p value 0.471p value 0.267
The Heidelberg Retina Tomograph-based macular volumetric quantification technique showed good reproducibility for volumetric measurements at the macula in normal subjects.
Good reproducibility for volumetric measurements at the macula was found with the HRT using the above technique in normal subjects.
Section: abstract
intrascan coefficient of variability 7.12-9.57%
The Heidelberg Retina Tomograph-based macular volumetric quantification technique showed good reproducibility for volumetric measurements at the macula in normal subjects.
Good reproducibility for volumetric measurements at the macula was found with the HRT using the above technique in normal subjects.
Section: abstract
intrascan coefficient of variability 7.12-9.57%
The Heidelberg Retina Tomograph-based macular volumetric quantification technique showed good reproducibility for volumetric measurements at the macula in normal subjects.
Good reproducibility for volumetric measurements at the macula was found with the HRT using the above technique in normal subjects.
Section: abstract
intrascan coefficient of variability 7.12-9.57%
The Heidelberg Retina Tomograph-based macular volumetric quantification technique showed good reproducibility for volumetric measurements at the macula in normal subjects.
Good reproducibility for volumetric measurements at the macula was found with the HRT using the above technique in normal subjects.
Section: abstract
intrascan coefficient of variability 7.12-9.57%
The Heidelberg Retina Tomograph-based macular volumetric quantification technique showed good reproducibility for volumetric measurements at the macula in normal subjects.
Good reproducibility for volumetric measurements at the macula was found with the HRT using the above technique in normal subjects.
Section: abstract
intrascan coefficient of variability 7.12-9.57%
The HRT-based macular volumetric method may be useful for identifying and quantifying diabetic macular oedema and for monitoring the effects of argon laser photocoagulation.
This method may be extremely useful for the identification and quantification of diabetic macular oedema and for monitoring the effects of argon laser photocoagulation.
Section: abstract
The HRT-based macular volumetric method may be useful for identifying and quantifying diabetic macular oedema and for monitoring the effects of argon laser photocoagulation.
This method may be extremely useful for the identification and quantification of diabetic macular oedema and for monitoring the effects of argon laser photocoagulation.
Section: abstract
The HRT-based macular volumetric method may be useful for identifying and quantifying diabetic macular oedema and for monitoring the effects of argon laser photocoagulation.
This method may be extremely useful for the identification and quantification of diabetic macular oedema and for monitoring the effects of argon laser photocoagulation.
Section: abstract
The HRT-based macular volumetric method may be useful for identifying and quantifying diabetic macular oedema and for monitoring the effects of argon laser photocoagulation.
This method may be extremely useful for the identification and quantification of diabetic macular oedema and for monitoring the effects of argon laser photocoagulation.
Section: abstract
The HRT-based macular volumetric method may be useful for identifying and quantifying diabetic macular oedema and for monitoring the effects of argon laser photocoagulation.
This method may be extremely useful for the identification and quantification of diabetic macular oedema and for monitoring the effects of argon laser photocoagulation.
Section: abstract
Approval Evidence
1 source5 linked approval claimsfirst-pass slug macular-volumetric-quantification-above-a-reference-plane
The authors describe a new technique for the assessment of macular thickening by volumetric quantification... The volumes above the reference plane bound by a 1 mm, 2 mm, and 3 mm diameter circle were measured.
Source:
associationsupports
The standard deviation of volumetric measurements increased significantly as volumetric measurements increased.
Linear regression demonstrated a significant increase in SD as volumetric measurements increased (p = 0.003).
Source:
measurement protocolsupports
The macular volumetric method measured volume above a reference plane within 1 mm, 2 mm, and 3 mm diameter circles centered on the fovea, with the reference plane adjusted to the lowest point of contour-line height variation at each examination.
The volumes above the reference plane bound by a 1 mm, 2 mm, and 3 mm diameter circle were measured. The reference plane was adjusted to the lowest point of the height variation of the contour line at each examination.
Source:
non associationsupports
Age did not significantly affect the standard deviation of volumetric measurements, and volumetric measurements did not differ significantly across ages for the 1 mm, 2 mm, and 3 mm circles.
Age did not significantly affect the SD of volumetric measurements (p = 0.797). The authors found no significant differences in volumetric measurements across all ages for all three circles (p = 0.314, p = 0.471, p = 0.267).
Source:
performancesupports
The Heidelberg Retina Tomograph-based macular volumetric quantification technique showed good reproducibility for volumetric measurements at the macula in normal subjects.
Good reproducibility for volumetric measurements at the macula was found with the HRT using the above technique in normal subjects.
Source:
potential applicationsupports
The HRT-based macular volumetric method may be useful for identifying and quantifying diabetic macular oedema and for monitoring the effects of argon laser photocoagulation.
This method may be extremely useful for the identification and quantification of diabetic macular oedema and for monitoring the effects of argon laser photocoagulation.
Source:
Comparisons
Source-backed strengths
The reported study found good reproducibility for macular volumetric measurements in normal subjects. The protocol uses predefined 1 mm, 2 mm, and 3 mm diameter circles centered on the fovea, and age did not significantly affect measurement standard deviation or measured volumes across these regions.
Ranked Citations
- 1.