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β2-integrin adhesion

Candidate: concept label1 source documents7 linked claims
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Aliases

β2-integrin-mediated adhesion, β2-integrins

Evidence Snippets

β2-integrins are known to restrict DC activation and migration... loss of β2-integrin adhesion leads to nuclear deformation and activation of a cPLA2-GADD34 pathway in BMDCs.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1gene expression changesupports2026Source 1DOIPubMed

GADD34 is upregulated in datasets associated with loss of β2-integrin adhesion and nuclear deformation.

Quoted textsource-backed
Growth arrest and DNA damage-inducible protein (GADD34; Ppp1r15) of the unfolded protein responses was also upregulated in both datasets.
Claim 2gene expression changesupports2026Source 1DOIPubMed

Loss of β2-integrin adhesion and nuclear deformation both upregulate dendritic-cell activation markers and cytokines including Ccr7, Cd86, and Il12b.

Quoted textsource-backed
Analysis of published gene expression data revealed that loss of β2-integrin adhesion and nuclear deformation both upregulate DC activation markers and cytokines, including Ccr7, Cd86, and Il12b.
Claim 3mechanistic modelsupports2026Source 1DOIPubMed

Loss of β2-integrin adhesion leads to nuclear deformation and activation of a cPLA2-GADD34 pathway that partly controls the activated phenotype of bone marrow-derived dendritic cells.

Quoted textsource-backed
Together, our results show that loss of β2-integrin adhesion leads to nuclear deformation and activation of a cPLA2-GADD34 pathway in BMDCs, which at least partly controls their activated phenotype.
Claim 4mechanistic regulationsupports2026Source 1DOIPubMed

cPLA2 controls interleukin-12 production and CD86 expression in β2-integrin adhesion-deficient bone marrow-derived dendritic cells.

Quoted textsource-backed
Utilizing a cytosolic phospholipase A2 (cPLA2) inhibitor, we show that the nuclear shape sensor cPLA2 controls interleukin-12 production and CD86 expression of β2-integrin adhesion-deficient BMDCs.
Claim 5mechanistic regulationsupports2026Source 1DOIPubMed

β2-integrins regulate podosome formation and nuclear morphology in bone marrow-derived dendritic cells on stiff and soft surfaces.

Quoted textsource-backed
Here, we show that β2-integrins regulate podosome formation as well as nuclear morphology of bone marrow-derived DCs (BMDCs) on both stiff and soft surfaces.
Claim 6pathway activationsupports2026Source 1DOIPubMed

The GADD34 pathway is activated in adhesion-deficient bone marrow-derived dendritic cells and is associated with reduced EIF2α phosphorylation.

Quoted textsource-backed
We further show that the GADD34 pathway is activated in adhesion-deficient BMDCs, as eukaryotic translation initiation factor 2A (EIF2α) phosphorylation is reduced in these cells
Claim 7perturbation effectsupports2026Source 1DOIPubMed

GADD34 inhibition decreases interleukin-12 production and CD86 expression in β2-integrin-deficient bone marrow-derived dendritic cells, whereas PERK inhibition has no effect.

Quoted textsource-backed
GADD34 inhibition led to decreased interleukin-12 production and CD86 expression in β2-integrin-deficient BMDCs, whilst inhibition of protein kinase R-like endoplasmic reticulum kinase (the canonical EIF2α kinase) had no effect.