Ten-Eleven Translocation family proteins-mediated hydroxylation of 5-mC to 5-hydroxymethylcytosine as additional active demethylation pathway are also discussed.
First-pass extracted concept
5-hydroxymethylcytosine
Candidate: concept label1 source documents4 linked claims
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Aliases
5-hmC
Evidence Snippets
Supporting Sources
Linked Claims
Combinatorial interactions among known modified DNA bases suggest a more complex epigenetic code than previously appreciated.
Quoted textsource-backed
The potential for combinatorial interaction among the known modified DNA bases suggests that epigenetic codon is likely to be substantially more complicated than it is thought today.
Modified DNA bases are associated with regulation of cellular and developmental processes, stem cell pluripotency, neuron development, and tumor development in animals.
Quoted textsource-backed
The epigenetic marks are known to be associated with the regulation of several cellular and developmental processes, pluripotency of stem cells, neuron cell development, and tumor development in animals.
TET family proteins mediate hydroxylation of 5-methylcytosine to 5-hydroxymethylcytosine as an active demethylation pathway.
Quoted textsource-backed
Ten-Eleven Translocation family proteins-mediated hydroxylation of 5-mC to 5-hydroxymethylcytosine as additional active demethylation pathway are also discussed.
DNA base modifications play important roles in epigenetic control of gene expression in animals and plants.
Quoted textsource-backed
Modification of DNA bases plays vital roles in the epigenetic control of gene expression in both animals and plants.