Though much attention is given to the conventional epigenetic signature 5-methylcytosine (5-mC), the field of epigenetics is attracting increased scientific interest through the discovery of additional modifications of DNA bases and their roles in controlling gene expression.
First-pass extracted concept
5-methylcytosine
Candidate: concept label1 source documents4 linked claims
Live refresh every 5sNext refresh in 5s
Aliases
5-mC
Evidence Snippets
Supporting Sources
Linked Claims
Combinatorial interactions among known modified DNA bases suggest a more complex epigenetic code than previously appreciated.
Quoted textsource-backed
The potential for combinatorial interaction among the known modified DNA bases suggests that epigenetic codon is likely to be substantially more complicated than it is thought today.
Modified DNA bases are associated with regulation of cellular and developmental processes, stem cell pluripotency, neuron development, and tumor development in animals.
Quoted textsource-backed
The epigenetic marks are known to be associated with the regulation of several cellular and developmental processes, pluripotency of stem cells, neuron cell development, and tumor development in animals.
DNA base modifications play important roles in epigenetic control of gene expression in animals and plants.
Quoted textsource-backed
Modification of DNA bases plays vital roles in the epigenetic control of gene expression in both animals and plants.
Among DNA bases, only cytosine and adenine modifications are stated as known in this review.
Quoted textsource-backed
Theoretically, each of the DNA bases can be modified; however, modifications of cytosine and adenine only are known so far.