First-pass extracted concept

53BP1 phase separation

Candidate: concept label1 source documents3 linked claims

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Evidence Snippets

Anchor paper confirmed: Kilic et al., EMBO Journal (2019) showed that 53BP1-marked DNA repair compartments display liquid-like, phase-separated behavior, identified sequence features supporting 53BP1 condensation, and linked disruption of 53BP1 phase separation to reduced p53 induction and downstream gene expression.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2019The EMBO JournalDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1functional effectsupports2019Source 1DOI PubMed

Disruption of 53BP1 phase separation is linked to reduced p53 induction and downstream gene expression.

Claim 2mechanisticsupports2019Source 1DOI PubMed

53BP1 determines the liquid-like behavior of DNA repair compartments through phase separation.

Claim 3mechanisticsupports2019Source 1DOI PubMed

Sequence features support 53BP1 condensation.