First-pass extracted concept

α7 nicotinic acetylcholine receptor-positive splenocytes

Candidate: concept label1 source documents4 linked claims

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Aliases

α7nAChR-positive splenocytes, α7nAChR+ splenocytes

Extracted Explainers

What the tool is doing

The abstract identifies α7nAChR-positive splenocytes as the cellular population required for VNS-mediated protection from kidney ischemia-reperfusion injury.

Source 1DOI PubMed

Evidence Snippets

Together, these results demonstrate that VNS-mediated attenuation of AKI and systemic inflammation depends on α7nAChR-positive splenocytes.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2016Journal of Clinical InvestigationDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1dependencysupports2016Source 1DOI PubMed

The protective effect of vagus nerve stimulation against kidney ischemia-reperfusion injury is abolished by prior splenectomy.

Claim 2genetic dependencysupports2016Source 1DOI PubMed

Prior vagus nerve stimulation does not prevent kidney ischemia-reperfusion injury in mice lacking α7nAChR.

Claim 3mechanismsupports2016Source 1DOI PubMed

Vagus nerve stimulation-mediated attenuation of acute kidney injury and systemic inflammation depends on α7nAChR-positive splenocytes.

Claim 4transferabilitysupports2016Source 1DOI PubMed

Adoptive transfer of VNS-conditioned α7nAChR splenocytes confers protection to recipient mice subjected to kidney ischemia-reperfusion injury.