First-pass extracted concept

A-kinase-anchoring proteins

Candidate: concept label1 source documents4 linked claims

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Aliases

AKAPs

Extracted Explainers

What the tool is doing

A-kinase-anchoring proteins are described as factors that refine compartmentalization of cAMP signaling.

Source 1DOI PubMed

What problem it solves

They provide spatial organization of cAMP signaling, which the review links to memory-relevant signaling specificity.

Source 1DOI PubMed

Evidence Snippets

and via A-kinase-anchoring proteins that refine signal compartmentalization of cAMP signaling

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2020Neuroscience & Biobehavioral ReviewsDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1mechanistic summarysupports2020Source 1DOI PubMed

A-kinase-anchoring proteins refine compartmentalization of cAMP signaling.

Claim 2review summarysupports2020Source 1DOI PubMed

Altered cyclic nucleotide signaling has been implicated in the pathophysiology of mnemonic dysfunction in several diseases.

Claim 3review summarysupports2020Source 1DOI PubMed

cAMP and cGMP cascades play important roles in neuronal plasticity and memory function.

Claim 4timing summarysupports2020Source 1DOI PubMed

Specific time windows in cyclic nucleotide signaling during neuroplasticity and memory formation are important and may be targetable to improve memory formation.