First-pass extracted concept

AARS1

Candidate: concept label1 source documents4 linked claims

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Aliases

alanyl-tRNA synthetase 1

Extracted Explainers

What the tool is doing

The abstract describes AARS1 as an aminoacyl-tRNA synthetase with emerging translation-independent roles as a lactate sensor and lactyltransferase in cancer.

Source 1DOI PubMed

What problem it solves

The review frames AARS1 as helping explain how elevated lactate can be linked mechanistically to oncogenic signaling through lysine lactylation.

Source 1DOI PubMed

Evidence Snippets

Current research has highlighted AARS1/2 as lactate sensors and lactyltransferases that catalyze global lysine lactylation in cancer cells and promote cancer proliferation.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1disease associationsupports2025Source 1DOI PubMed

AARS1 and AARS2 promote cancer proliferation through lactylation-related mechanisms.

Claim 2mechanistic rolesupports2025Source 1DOI PubMed

AARS1 and AARS2 are highlighted as lactate sensors and lactyltransferases that catalyze global lysine lactylation in cancer cells.

Claim 3pathway linksupports2025Source 1DOI PubMed

Lactylation acts as a mechanistic bridge linking AARS1 and AARS2 to oncogenic signaling pathways associated with metabolic reprogramming, uncontrolled proliferation, immune escape, and therapy resistance.

Claim 4therapeutic implicationsupports2025Source 1DOI PubMed

Targeting AARS1 or AARS2 or modulating related lactylation is proposed as a potential cancer therapy strategy.