Intersectional cell type-specific and input-output defined optogenetic activation of this ACB-LHA-LHb pathway can progressively induce a negative behavioral state that depends on Esr1+ LHA-LHb neural activity.
First-pass extracted concept
ACB-LHA-LHb pathway
Candidate: concept label1 source documents3 linked claims
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Aliases
striosomal accumbens pathway, Tac1+ striosomal ACB projection targeting the Esr1+ LHA-LHb pathway
Evidence Snippets
Supporting Sources
Linked Claims
The induced stereotyped behaviors compete with highly motivated states and can override the drive for natural rewards or social interactions.
Quoted textsource-backed
We found that these complex yet stereotyped behaviors compete with highly motivated states and can override the drive for natural rewards or social interactions.
A discrete Tac1+ striosomal ACB projection targeting the aversive Esr1+ LHA-LHb pathway promotes stereotyped and compulsive-like behaviors over goal-directed actions.
Quoted textsource-backed
Our findings reveal a discrete Tac1+ striosomal ACB projection targeting the aversive Esr1+ LHA-LHb pathway as a key circuit that promotes stereotyped and compulsive-like behaviors over goal-directed actions.
Intersectional cell type-specific and input-output defined optogenetic activation of the ACB-LHA-LHb pathway progressively induces a negative behavioral state that depends on Esr1+ LHA-LHb neural activity.
Quoted textsource-backed
Intersectional cell type-specific and input-output defined optogenetic activation of this ACB-LHA-LHb pathway can progressively induce a negative behavioral state that depends on Esr1+ LHA-LHb neural activity.