our results suggest monosynaptic release of both GABA and ACh
First-pass extracted concept
acetylcholine/GABA corelease from cholinergic forebrain neurons
Candidate: concept label1 source documents5 linked claims
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Aliases
GABA/ACh corelease, monosynaptic release of both GABA and ACh
Evidence Snippets
Supporting Sources
Linked Claims
GABA is a fast neurotransmitter utilized throughout the forebrain cholinergic system.
Quoted textsource-backed
Our results identify GABA as an overlooked fast neurotransmitter utilized throughout the forebrain cholinergic system.
Optogenetic activation of choline acetyltransferase-expressing forebrain neurons evoked postsynaptic currents in layer 1 interneurons mediated by GABAA receptors as well as nicotinic acetylcholine receptors.
Quoted textsource-backed
we activated choline acetyltransferase expressing neurons using channelrhodopsin while recording post-synaptic currents (PSCs) in layer 1 interneurons. Surprisingly, we observed PSCs mediated by GABAA receptors in addition to nicotinic acetylcholine receptors.
Knocking out Slc32a1 from cholinergic neurons confirmed direct GABA release from those neurons.
Quoted textsource-backed
We confirmed the direct release of GABA by knocking out Slc32a1 from cholinergic neurons.
PSC latency and pharmacological sensitivity suggest monosynaptic release of both GABA and acetylcholine from cholinergic forebrain neurons.
Quoted textsource-backed
Based on PSC latency and pharmacological sensitivity, our results suggest monosynaptic release of both GABA and ACh.
Forebrain cholinergic neurons express Gad2 and Slc32a1.
Quoted textsource-backed
Anatomical analysis showed that forebrain cholinergic neurons express the GABA synthetic enzyme Gad2 and the vesicular GABA transporter (Slc32a1).