Long-range axons of cholinergic neurons regulate higher-order cognitive function and dysfunction in the neocortex by releasing acetylcholine (ACh). ACh release dynamically reconfigures neocortical microcircuitry through differential spatiotemporal actions on cell-types and their synaptic connections.
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acetylcholine signaling in the neocortex
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At the cellular level, acetylcholine controls neuronal excitability and firing rate by either hyperpolarizing or depolarizing target neurons.
Quoted textsource-backed
At the cellular level, ACh release controls neuronal excitability and firing rate, by hyperpolarizing or depolarizing target neurons.
Acetylcholine dynamically reconfigures neocortical microcircuitry through differential spatiotemporal actions on cell types and synaptic connections.
Quoted textsource-backed
ACh release dynamically reconfigures neocortical microcircuitry through differential spatiotemporal actions on cell-types and their synaptic connections.
Basal forebrain cholinergic projections densely innervate the neocortex and regulate higher-order cognitive function through acetylcholine release.
Quoted textsource-backed
The neocortex is densely innervated by basal forebrain (BF) cholinergic neurons. Long-range axons of cholinergic neurons regulate higher-order cognitive function and dysfunction in the neocortex by releasing acetylcholine (ACh).
At the synaptic level, acetylcholine alters both presynaptic release probability and the magnitude of postsynaptic responses.
Quoted textsource-backed
At the synaptic level, ACh impacts transmission dynamics not only by altering the presynaptic probability of release, but also the magnitude of the postsynaptic response.