First-pass extracted concept

acetylcholine signaling in the striatum

Candidate: concept label1 source documents4 linked claims

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Aliases

ACh

Evidence Snippets

Relative to other brain areas, the striatum contains exceptionally high levels of ACh, the enzymes that catalyze its synthesis and breakdown, as well as both nicotinic and muscarinic receptor types that mediate its postsynaptic effects.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2014Frontiers in Synaptic NeuroscienceDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1abundance or distributionsupports2014Source 1DOI PubMed

The striatum contains exceptionally high levels of acetylcholine and related synthetic, degradative, and receptor machinery compared with other brain areas.

Claim 2functional rolesupports2014Source 1DOI PubMed

The striatum plays a central role in motor control and motor learning.

Claim 3review scope statementsupports2014Source 1DOI PubMed

The review covers factors affecting cholinergic interneuron excitability through acute effects and long-term changes in synaptic inputs, as well as physiological effects of acetylcholine in the striatum and disease relevance.

Claim 4source of signalsupports2014Source 1DOI PubMed

Striatal cholinergic interneurons are the principal source of acetylcholine in the striatum.