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acidic tumor microenvironment

Candidate: concept label1 source documents3 linked claims
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Aliases

acidic TME

Extracted Explainers

What the tool is doing

The acidic tumor microenvironment is presented as a tumor-associated condition arising mainly from high glycolytic activity of tumor cells. The article frames it as a targetable feature for smart cancer nano-theranostics.

Source 1DOI

Resources required

Using this feature requires pH-responsive nanoscale theranostic platforms designed to respond to acidic tumor conditions.

Source 1DOI

What problem it solves

It offers a cancer-associated targeting cue for more precise imaging and treatment.

Source 1DOI

Alternatives

The abstract does not name alternative tumor-targeting cues.

Source 1DOI

Evidence Snippets

The acidic tumor microenvironment (TME) ... has been characterized as a hallmark of solid tumors ... the acidic TME could be utilized as a multifaceted target during the design of various pH-responsive nanoscale theranostic platforms
Evidence 1Source 1DOIprovenance

Supporting Sources

Linked Claims

Claim 1disease associationsupports2017Source 1DOI

The acidic tumor microenvironment is a hallmark of solid tumors and participates in tumor progression.

Quoted textsource-backed
has been characterized as a hallmark of solid tumors and found to be a pivotal factor participating in tumor progression
Claim 2mechanistic contextsupports2017Source 1DOI

The acidic tumor microenvironment mainly results from the high glycolytic rate of tumor cells.

Quoted textsource-backed
The acidic tumor microenvironment (TME), which mainly results from the high glycolytic rate of tumor cells
Claim 3use casesupports2017Source 1DOI

The acidic tumor microenvironment can be used as a multifaceted target in the design of pH-responsive nanoscale theranostic platforms.

Quoted textsource-backed
the acidic TME could be utilized as a multifaceted target during the design of various pH-responsive nanoscale theranostic platforms