First-pass extracted concept

Activation-induced cytidine deaminase

Candidate: concept label1 source documents5 linked claims

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Aliases

AID

Extracted Explainers

What the tool is doing

The abstract describes AID as a DNA deaminase in B lymphocytes that supports antibody diversification by introducing DNA mutations. It is also described as having a proposed DNA demethylation function.

Source 1DOI PubMed

What problem it solves

In normal physiology, AID helps diversify antibodies by changing specificity and affinity.

Source 1DOI PubMed

What it does not solve

The abstract does not present AID as a general-purpose engineering reagent or therapeutic solution. Instead, deregulated AID is linked to carcinogenesis.

Source 1DOI PubMed

Alternatives

The supplied abstract does not name alternative tools or substitute systems.

Source 1DOI PubMed

Evidence Snippets

Activation Induced cytidine Deaminase (AID) is an essential enzyme of the adaptive immune system.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2020Journal of Cancer Research and Clinical OncologyDOI PubMed

1 evidence snippet 5 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1biological rolesupports2020Source 1DOI PubMed

AID is an essential adaptive immune enzyme whose canonical activity in B lymphocytes supports antibody diversification through DNA deamination.

Claim 2disease associationsupports2020Source 1DOI PubMed

Adverse cellular conditions such as chronic inflammation can deregulate and overexpress AID.

Claim 3disease associationsupports2020Source 1DOI PubMed

Deregulated AID is described as an important driver of B-cell lymphoma through DNA deamination-associated mutations and epigenetic changes.

Claim 4disease associationsupports2020Source 1DOI PubMed

The review states that AID deregulation is not restricted to lymphoid cells and has been implicated in non-lymphoid cancers.

Claim 5mechanism summarysupports2020Source 1DOI PubMed

The review describes AID as having an additional assigned function as a DNA demethylator.