First-pass extracted concept

activity-dependent myelination

Candidate: concept label1 source documents3 linked claims

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Aliases

adaptive myelination

Extracted Explainers

What the tool is doing

This concept describes a mode of myelination in which nervous system activity drives plastic changes in myelin-forming cells and myelin structure. The review presents it as complementary to activity-independent developmental myelination.

Source 1DOI PubMed

What problem it solves

It helps explain how experience and neural activity could modify myelin and thereby influence circuit function and cognition.

Source 1DOI PubMed

What it does not solve

It does not specify a single experimental construct, delivery system, or assay implementation in the abstract.

Source 1DOI PubMed

Alternatives

The abstract contrasts this concept with activity-independent myelination as the other major mode of myelin development.

Source 1DOI PubMed

Evidence Snippets

Although an innate program of myelin development proceeds independent of nervous system activity, a second mode of myelination exists in which activity-dependent, plastic changes in myelin-forming cells influence myelin structure and neurological function.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2018Annual Review of NeuroscienceDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1review summarysupports2018Source 1DOI PubMed

Activity-dependent plastic changes in myelin-forming cells influence myelin structure and neurological function.

Quoted textsource-backed

a second mode of myelination exists in which activity-dependent, plastic changes in myelin-forming cells influence myelin structure and neurological function

Claim 2review summarysupports2018Source 1DOI PubMed

Activity-independent and activity-dependent myelination may be complementary and temporally overlapping, together forming a model of experience-modulated myelin development and plasticity.

Quoted textsource-backed

These complementary and possibly temporally overlapping activity-independent and activity-dependent modes of myelination crystallize in a model of experience-modulated myelin development and plasticity

Claim 3review summarysupports2018Source 1DOI PubMed

Myelin development includes an activity-independent innate program and an activity-dependent plastic mode.

Quoted textsource-backed

Although an innate program of myelin development proceeds independent of nervous system activity, a second mode of myelination exists in which activity-dependent, plastic changes in myelin-forming cells influence myelin structure and neurological function.