It is concluded that the rodent's behavioural response to a forced swim stressor does not reflect depression. Rather the forced swim experience provides a unique paradigm to investigate the mechanistic underpinning of stress coping and adaptation.
First-pass extracted concept
adaptive coping interpretation of forced-swim immobility
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The review argues that rodent behavior in the forced swim test reflects stress coping and adaptation rather than depression.
Quoted textsource-backed
It is concluded that the rodent's behavioural response to a forced swim stressor does not reflect depression. Rather the forced swim experience provides a unique paradigm to investigate the mechanistic underpinning of stress coping and adaptation.
The review proposes that after rescue from the beaker, the preferred coping style is stored in memory through a GR-dependent action in the hippocampal dentate gyrus.
Quoted textsource-backed
Upon rescue from the beaker the preferred, mostly passive, coping style is stored in the memory via a GR-dependent action in the hippocampal dentate gyrus.
The review proposes that corticosterone acting through MR and GR in limbic brain circuits contributes to coping-related information processing during forced swim stress.
Quoted textsource-backed
For this purpose we focus on the action of corticosterone that is mediated by the closely related mineralocorticoid receptors (MR) and glucocorticoid receptors (GR) in the limbic brain.
The review proposes that limbic MR-mediated response selection works with dopaminergic accumbens and prefrontal executive functions to regulate the transition between active and passive coping styles.
Quoted textsource-backed
The evidence available suggests a model in which we propose that the limbic MR-mediated response selection operates in complementary fashion with dopaminergic accumbens/prefrontal executive functions to regulate the transition between active and passive coping styles.