First-pass extracted concept

adeno-associated virus donor vectors

Candidate: concept label1 source documents3 linked claims

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Aliases

AAV donor vectors, linear AAV donors

Evidence Snippets

Using both plasmid and adeno-associated virus (AAV) donor vectors

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2026MEDDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1design principlesupports2026Source 1DOI PubMed

Donor DNA configuration critically influences DNA damage response signaling during targeted insertion.

Quoted textsource-backed

These findings highlight the critical influence of donor DNA configuration on DNA damage response signaling

Claim 2mechanistic effectsupports2026Source 1DOI PubMed

With linear AAV donors, ATM inhibition enhanced knock-in efficiency by suppressing overactivation of the ATM-p53-caspase 3 apoptotic pathway and partially suppressing classical non-homologous end-joining.

Quoted textsource-backed

with linear AAV donors, ATM inhibition enhanced the knock-in efficiency by suppressing the overactivation of the ATM-p53-caspase 3 apoptotic pathway and partially suppressing classical non-homologous end-joining

Claim 3mechanistic requirementsupports2026Source 1DOI PubMed

ATR activity is essential for knock-in regardless of whether plasmid or AAV donor vectors are used.

Quoted textsource-backed

ATR activity is essential for knock-in regardless of the donor type