Bone marrow transplant studies and quantitation of macrophage number in adipose tissue from macrophage-deficient (Csf1 op/op ) mice suggest that these F4/80 + cells are CSF-1 dependent, bone marrow-derived adipose tissue macrophages.
First-pass extracted concept
adipose tissue macrophages
Candidate: concept label1 source documents7 linked claims
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Aliases
adipose tissue macrophages, F4/80+ cells
Evidence Snippets
Supporting Sources
Linked Claims
Obesity is associated with increased macrophage accumulation in adipose tissue.
The F4/80-positive cells in adipose tissue are suggested to be CSF-1-dependent, bone marrow-derived adipose tissue macrophages.
Adipose tissue macrophages are responsible for almost all adipose tissue TNF-alpha expression and significant amounts of iNOS and IL-6 expression.
Among the 100 most significantly body-mass-correlated genes, 30% encoded proteins characteristic of macrophages and were positively correlated with body mass.
In mouse adipose depots, the percentage of F4/80-positive cells was significantly and positively correlated with adipocyte size and body mass.
In human subcutaneous adipose tissue, CD68 staining showed relationships similar to those observed in mouse adipose tissue between macrophage marker-positive cells and adiposity-related features.
In mouse perigonadal adipose tissue, expression of 1,304 transcripts correlated significantly with body mass.