First-pass extracted concept

adult hippocampal neurogenesis

Candidate: concept label2 source documents5 linked claims

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Extracted Explainers

What the tool is doing

This term refers to the generation of new neurons in the adult hippocampus, which the review discusses as an established cellular mechanism in the adult mammalian brain.

Source 1DOI PubMed

What problem it solves

It frames the main subject of the review, including evidence for existence, aging-related decline, regulation, and function.

Source 1DOI PubMed

What it does not solve

It is not itself a method, construct, or assay that can be directly implemented as a toolkit item.

Source 1DOI PubMed

Alternatives

The abstract also refers more broadly to new neuron generation in the adult mammalian CNS, but the review is specifically centered on hippocampal neurogenesis.

Source 1DOI PubMed

Evidence Snippets

After several technological advancements had been made in the field, we published a paper in 1996 describing the generation of new neurons in the adult rat brain and the decline of hippocampal neurogenesis during aging.

Evidence 1Source 1DOI PubMedprovenance

Adult Hippocampal Neurogenesis, Fear Generalization, and Stress

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1review2018Journal of NeuroscienceDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Source 2review2015NeuropsychopharmacologyDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Linked Claims

Claim 1aging effect summarysupports2018Source 1DOI PubMed

The authors' 1996 study described generation of new neurons in the adult rat brain and a decline of hippocampal neurogenesis during aging.

Quoted textsource-backed

we published a paper in 1996 describing the generation of new neurons in the adult rat brain and the decline of hippocampal neurogenesis during aging

Claim 2historical summarysupports2018Source 1DOI PubMed

Adult mammalian CNS neurogenesis was previously debated but became established as a cellular mechanism after technological advances and convergent studies in the 1990s.

Quoted textsource-backed

What has become standard textbook knowledge over the last decade was a hotly debated matter a decade earlier: the proposition that new neurons are generated in the adult mammalian CNS... After several technological advancements had been made in the field... The paper coincided with the publication of several other studies that together established neurogenesis as a cellular mechanism in the adult mammalian brain.

Claim 3methodological needsupports2018Source 1DOI PubMed

Early work on adult neurogenesis was vulnerable to criticism because technical strategies for unequivocal demonstration, quantification, and physiological analysis of newly generated neurons in adult brain tissue were lacking.

Quoted textsource-backed

The early discovery by Altman and colleagues in the 1960s was vulnerable to criticism due to the lack of technical strategies for unequivocal demonstration, quantification, and physiological analysis of newly generated neurons in adult brain tissue.

Claim 4open questionneutral2018Source 1DOI PubMed

Questions remain regarding the regulation and function of adult mammalian neurogenesis, particularly the existence of neurogenesis in the adult human brain.

Quoted textsource-backed

We also address questions that remain regarding the regulation and function of neurogenesis in the adult mammalian brain, in particular the existence of neurogenesis in the adult human brain.

Claim 5cellular mechanism summarysupports2015Source 2DOI PubMed

Adult-born dentate granule cells are discussed as modulators of pattern separation that influence interference resolution and maintenance of remote aversive memory precision.

Quoted textsource-backed

We invoke cellular-, circuit-, and systems-based mechanisms by which adult-born dentate granule cells (DGCs) modulate pattern separation to influence resolution of interference and maintain precision of remote aversive memories.