with two proteins remaining significant after multiple testing correction: complement C4A (C4A) and afamin (AFM).
First-pass extracted concept
Afamin (AFM)
Candidate: concept label1 source documents6 linked claims
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Aliases
AFM
Evidence Snippets
Supporting Sources
Linked Claims
INHBE and AFM merit validation as candidate biomarkers and potential contributors to MASLD in postmenopausal women.
Quoted textsource-backed
While exploratory, candidate EV proteins such as INHBE and AFM merit validation as biomarkers and potential contributors to MASLD in this high-risk population.
AFM and C4A were the only two EV proteins that remained significant after multiple testing correction.
Quoted textsource-backed
with two proteins remaining significant after multiple testing correction: complement C4A (C4A) and afamin (AFM)
In severe hepatic steatosis, EV subgroup analysis showed increased COL18A1, AFM, PRG4, and INHBE and decreased C4A and APOA1.
Quoted textsource-backed
In participants with severe hepatic steatosis (n = 43), subgroup analysis showed increased COL18A1, AFM, PRG4, and INHBE and decreased C4A and APOA1.
In Black women, AFM, C4A, and APOA1 were significantly elevated in the EV proteome subgroup analysis.
Quoted textsource-backed
In Black women (n = 172), AFM, C4A, and APOA1 were significantly elevated
In White participants, no EV proteins reached significance, although AFM showed a nonsignificant trend toward higher abundance.
Quoted textsource-backed
while in White participants (n = 103), no proteins reached significance, although AFM displayed a nonsignificant trend toward higher abundance
AFM expression was significantly higher in the MASH versus steatosis comparison in hepatic transcriptomic datasets.
Quoted textsource-backed
while AFM expression was significantly higher in the MASH vs. steatosis comparison