First-pass extracted concept

African dormouse MPXV model

Candidate: concept label1 source documents6 linked claims

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Aliases

African dormouse (Graphiurus spp.) model

Extracted Explainers

What the tool is doing

The paper establishes African dormice as an animal model for MPXV infection, pathogenicity, and transmission studies. The model supports challenge, contact transmission, and aerosol shedding characterization.

Source 1DOI PubMed

Resources required

The abstract supports the need for African dormice and intranasal inoculation with an MPXV clade IIb strain. Transmission and aerosol analyses are also part of the reported model use.

Source 1DOI PubMed

What problem it solves

It addresses the shortage of reliable and consistent animal models for MPXV evaluation. The model is presented as suitable for assessing infection, pathogenicity, and transmission.

Source 1DOI PubMed

What it does not solve

The abstract indicates that airborne transmission is relatively limited in this model. It does not establish robust airborne infection with detectable infectious virus in respiratory tissues of exposed animals.

Source 1DOI PubMed

Alternatives

The abstract only states that reliable and consistent animal models remain limited, without naming specific alternative models in the source text provided.

Source 1DOI PubMed

Evidence Snippets

This study established an African dormouse (Graphiurus spp.) model and systematically characterized the pathogenicity and transmissibility of a clade IIb strain.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2026MEDDOI PubMed

1 evidence snippet 6 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1aerosol sheddingsupports2026Source 1DOI PubMed

MPXV-infected African dormice continuously release large quantities of virus-laden aerosols, peaking at 12 days post-infection.

Claim 2model establishmentsupports2026Source 1DOI PubMed

African dormice are a suitable animal model for assessing MPXV infection, pathogenicity, and transmission.

Claim 3particle distributionsupports2026Source 1DOI PubMed

During peak shedding, more than 90.9% of exhaled viral aerosol copies were in coarse particles of at least 7 micrometers.

Claim 4pathogenicitysupports2026Source 1DOI PubMed

African dormice are highly susceptible to MPXV infection after intranasal inoculation, showing significant weight loss, lethal infection, multi-organ pathology, and robust viral replication in respiratory and liver tissues.

Claim 5transmissionsupports2026Source 1DOI PubMed

Airborne transmissibility of MPXV among African dormice is relatively limited.

Claim 6transmissionsupports2026Source 1DOI PubMed

MPXV transmits efficiently among African dormice through direct contact.