Agouti-related-peptide (AgRP) neurons-interoceptive neurons in the arcuate nucleus of the hypothalamus (ARC)-are both necessary and sufficient for driving feeding behavior.
First-pass extracted concept
AgRP neurons
Candidate: concept label1 source documents7 linked claims
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Aliases
agouti-related-peptide neurons
Evidence Snippets
Supporting Sources
Linked Claims
In food-restricted mice, AgRP neuron firing dropped when food became available but remained elevated relative to sated mice.
Quoted textsource-backed
In food-restricted mice, as food became available, AgRP neuron firing dropped, yet remained elevated as compared to firing in sated mice.
In free-feeding mice, AgRP neuron firing increased fivefold with mounting caloric deficit in afternoon versus morning recordings.
Quoted textsource-backed
In free-feeding mice, we observed a fivefold increase in AgRP neuron firing with mounting caloric deficit in afternoon vs morning recordings.
AgRP neurons are necessary and sufficient for driving feeding behavior.
Quoted textsource-backed
Agouti-related-peptide (AgRP) neurons-interoceptive neurons in the arcuate nucleus of the hypothalamus (ARC)-are both necessary and sufficient for driving feeding behavior.
The rapid drop in AgRP neuron spiking at meal onset may reflect termination of the drive to find food, whereas residual persistent spiking may reflect a sustained drive to consume food.
Quoted textsource-backed
The rapid drop in spiking activity of AgRP neurons at meal onset may reflect a termination of the drive to find food, while residual, persistent spiking may reflect a sustained drive to consume food.
Nearby neurons inhibited by AgRP neuron photostimulation, likely including POMC neurons, showed opposite changes in spiking relative to AgRP neurons.
Quoted textsource-backed
Moreover, nearby neurons inhibited by AgRP neuron photostimulation, likely including satiety-promoting pro-opiomelanocortin (POMC) neurons, demonstrated opposite changes in spiking.
AgRP and putative POMC neurons have antagonistic roles in regulating feeding behaviors across multiple timescales.
Quoted textsource-backed
These findings suggest novel roles for antagonistic AgRP and POMC neurons in the regulation of feeding behaviors across multiple timescales.
Firing of arcuate nucleus neurons was rapidly modulated within seconds of individual licks for liquid food.
Quoted textsource-backed
Finally, firing of ARC neurons was also rapidly modulated within seconds of individual licks for liquid food.