In this Review, we appraise a decade of advances that define near-term (immediate) translation based on all-optical electrophysiology, including high-throughput screening, cardiotoxicity testing and personalized medicine assays.
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all-optical electrophysiology
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Evidence Snippets
The review explicitly centers optogenetic/all-optical electrophysiology for phenotypic screening.
Here we review the fundamental aspects of bioelectricity with the aim of laying a conceptual framework for all-optical electrophysiology.
Supporting Sources
Linked Claims
Advances in cardiac optogenetics define near-term translational opportunities based on all-optical electrophysiology for high-throughput screening, cardiotoxicity testing, and personalized medicine assays.
Quoted textsource-backed
In this Review, we appraise a decade of advances that define near-term (immediate) translation based on all-optical electrophysiology, including high-throughput screening, cardiotoxicity testing and personalized medicine assays.
This review centers optogenetic and all-optical electrophysiology approaches for phenotypic screening in drug discovery.
Optogenetic tools are not electrodes, so optical and electrode-based measurements have different quirks.
Quoted textsource-backed
Optogenetic tools are not electrodes; thus, optical and electrode-based measurements have different quirks.
Combining optical perturbation with optical readout of membrane voltage enables electrophysiology studies in systems that were previously inaccessible to electrode-based measurements.
Quoted textsource-backed
The combination of optical perturbation and optical readout of membrane voltage opens the door to studies of electrophysiology in a huge variety of systems previously inaccessible to electrode-based measurements.