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alpha-hydroxy-1,N(2)-propano-2'-deoxyguanosine

Candidate: concept label1 source documents5 linked claims
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Aliases

alpha-HOPdG, alpha-OH-PdG

Extracted Explainers

What the tool is doing

This is a minor acrolein-derived deoxyguanosine adduct discussed as a distinct lesion with mutagenic behavior. The review contrasts it with gamma-HOPdG because the two adducts behave differently in mutagenicity.

Source 1DOIPubMed

What problem it solves

It helps explain how acrolein can remain mutagenic even when the major adduct gives conflicting results. Its persistence is presented as a possible contributor to in vivo mutagenic burden.

Source 1DOIPubMed

What it does not solve

The review states that the role of alpha-HOPdG in acrolein mutagenicity still needs further investigation. It therefore does not fully resolve the overall mechanism by itself.

Source 1DOIPubMed

Alternatives

The main contrasted lesion in the review is gamma-HOPdG, the major acrolein adduct. The review emphasizes that the two isomers differ in abundance, repair, and mutagenic outcome.

Source 1DOIPubMed

Evidence Snippets

Reaction of acrolein with deoxyguanosine generates alpha-hydroxy-1, N(2)-propano-2'-deoxyguanosine (alpha-HOPdG) and gamma-hydroxy-1, N(2)-propano-2'-deoxyguanosine (gamma-HOPdG) adducts.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1comparative mutagenicitysupports2010Source 1DOIPubMed

Alpha-HOPdG and gamma-HOPdG differ in mutagenic behavior, with gamma-HOPdG being the major adduct and alpha-HOPdG being less abundant but harder to repair.

Claim 2evidence conflict summarysupports2010Source 1DOIPubMed

Inconsistent results in acrolein mutagenicity studies are attributed at least partly to formation of multiple acrolein-DNA adducts and their differential repair in diverse detection systems.

Claim 3human relevance summarysupports2010Source 1DOIPubMed

Detection of acrolein-DNA adducts in human lung tissues and analysis of p53 mutation spectra in acrolein-treated cells may inform mechanisms of acrolein mutagenicity.

Claim 4mechanistic summarysupports2010Source 1DOIPubMed

Acrolein mutagenicity relies on formation of DNA adducts.

Claim 5mutagenicity summarysupports2010Source 1DOIPubMed

Alpha-HOPdG is mutagenic in both in vitro and in vivo test systems and may accumulate in vivo because it is difficult to repair.