alphavirus assembly and budding

Deciphering the molecular mechanisms of alphavirus assembly and budding has been a central research frontier.

Alphaviruses are an escalating global concern because of substantial clinical impact and expanding geographic distribution.

Mechanistic understanding of the alphavirus life cycle is needed to guide rational intervention strategies.

An integrated understanding of viral and host factors and the spatial and temporal coordination of events across the alphavirus life cycle is important for addressing mechanistic gaps and guiding next-generation antiviral and vaccine strategies.

The perspective integrates research on viral RNA encapsidation, virus architecture, and the functions of host factors, membranes, and cytoskeletal components.

Most alphaviruses lack licensed therapies, and vector control is only partially effective.