This concept marks the disease context in which TDP-43 mislocalization is reviewed.
First-pass extracted concept
amyotrophic lateral sclerosis
Candidate: concept label3 source documents5 linked claims
Live refresh every 5sNext refresh in 5s
Aliases
ALS
Extracted Explainers
Evidence Snippets
Mutations in genes that encode essential autophagy factors result in impaired autophagy and lead to neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS).
healthy and amyotrophic lateral sclerosis stem cells
The role of TDP-43 mislocalization in amyotrophic lateral sclerosis
Supporting Sources
Linked Claims
Mutations in genes encoding essential autophagy factors impair autophagy and are linked to ALS.
Quoted textsource-backed
Mutations in genes that encode essential autophagy factors result in impaired autophagy and lead to neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS).
The contribution of non-cell autonomous autophagy dysfunction to ALS pathogenesis is not fully understood.
Quoted textsource-backed
Further, the manner and extent to which non-cell autonomous effects of autophagy dysfunction contribute to ALS pathogenesis are not fully understood.
The review covers critical autophagy steps, ALS-mutated factors that impair autophagy, their effects in disease models, and cell type-specific regulation in non-neuronal cells relevant to neurodegeneration.
Quoted textsource-backed
Here, we review the current understanding of the interplay between autophagy and ALS pathogenesis by providing an overview of critical steps in the autophagy pathway, with special focus on pivotal factors impaired by ALS-causing mutations, their physiologic effects on autophagy in disease models, and the cell type-specific mechanisms regulating autophagy in non-neuronal cells which, when impaired, can contribute to neurodegeneration.
The review proposes that understanding neuronal autophagy can help refine therapeutic strategies for ALS and related neurodegenerative diseases.
Quoted textsource-backed
This review thereby provides a framework not only to guide further investigations of neuronal autophagy but also to refine therapeutic strategies for ALS and related neurodegenerative diseases.
This review focuses on the role of TDP-43 mislocalization in amyotrophic lateral sclerosis.
Quoted textsource-backed
The role of TDP-43 mislocalization in amyotrophic lateral sclerosis