animal models of epilepsy

Major uses and limitations of epilepsy animal models can be assessed by comparing neuropathological, behavioral, and neurophysiological similarities and differences between each model and the human condition.

Appropriate animal models are essential because the mechanisms of epileptogenesis and seizure generation cannot be fully understood from human clinical studies alone.

The review covers chronic epilepsy models, acute seizure models induced by chemoconvulsants, traumatic brain injury, and electrical or sound stimuli, as well as genetic absence seizure models and immature-brain seizure or status epilepticus models.