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animal models of major depression

Candidate: concept label1 source documents3 linked claims

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Evidence Snippets

Animal models of major depression: drawbacks and challenges

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2019Journal of Neural TransmissionDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1paradigm coveragesupports2019Source 1DOI PubMed

The review's discussed paradigm space includes chronic mild stress, learned helplessness, social defeat, olfactory bulbectomy, early-life stress, and Wistar-Kyoto rat models.

Claim 2review scopesupports2019Source 1DOI PubMed

The review is a broad critique of animal models for major depression that emphasizes drawbacks, challenges, and validity limitations.

Claim 3validity limitationsupports2019Source 1DOI PubMed

Animal models of major depression are discussed as having limitations in construct validity, face validity, and predictive validity.