First-pass extracted concept

anterior cingulate cortex

Candidate: concept label2 source documents5 linked claims

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Aliases

ACC

Extracted Explainers

What the tool is doing

The anterior cingulate cortex is presented as an mPFC subregion involved in pain-related emotional and cognitive processing.

Source 2DOI PubMed

What problem it solves

It provides subregional resolution for the review's claim that chronic pain does not affect all mPFC areas identically.

Source 2DOI PubMed

What it does not solve

The abstract does not specify how ACC activity would be measured or manipulated for therapy.

Source 2DOI PubMed

Evidence Snippets

The anterior cingulate cortex (ACC) stands out due to its involvement in top-down modulation of pain perception, its abnormal activity in chronic pain conditions, and its contribution to cognitive functions frequently impaired in chronic pain states.

Evidence 1Source 1DOI PubMedprovenance

The medial prefrontal cortex... comprises the anterior cingulate cortex, the prelimbic, and the infralimbic cortex... While the anterior cingulate cortex appears hyperactive...

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1primary paper2023MEDDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Source 2review2020International Journal of Molecular SciencesDOI PubMed

1 evidence snippet 2 linked claims Claim 1 Claim 2

Linked Claims

Claim 1disease mechanismsupports2023Source 1DOI PubMed

Chronic pain alters neuromodulator signaling in anterior cingulate cortex circuits to promote pathological hyperexcitability.

Quoted textsource-backed

how chronic pain alters their signaling in ACC circuits to promote pathological hyperexcitability

Claim 2functional rolesupports2023Source 1DOI PubMed

The anterior cingulate cortex is involved in top-down modulation of pain perception and shows abnormal activity in chronic pain conditions.

Quoted textsource-backed

The anterior cingulate cortex (ACC) stands out due to its involvement in top-down modulation of pain perception, its abnormal activity in chronic pain conditions

Claim 3mechanistic rolesupports2023Source 1DOI PubMed

Dopamine, norepinephrine, serotonin, and other neuromodulators control activity of the anterior cingulate cortex.

Quoted textsource-backed

we review the roles of the monoamines dopamine (DA), norepinephrine (NE), serotonin (5-HT), and other neuromodulators in controlling the activity of the ACC

Claim 4activity state summarysupports2020Source 2DOI PubMed

In chronic pain, anterior cingulate cortex appears hyperactive whereas prelimbic and infralimbic regions show reduced activity.

Quoted textsource-backed

While the anterior cingulate cortex appears hyperactive, prelimbic, and infralimbic regions show reduced activity.

Claim 5anatomical change summarysupports2020Source 2DOI PubMed

Chronic pain conditions are associated with gray matter loss in anterior cingulate, prelimbic, and infralimbic regions of the medial prefrontal cortex.

Quoted textsource-backed

magnetic resonance imaging has revealed gray matter loss in all these areas in chronic pain conditions