various pharmacological and dietary approaches to enhance lung antioxidant levels and beneficial effects of antioxidant therapeutics in treating or intervening the progression of COPD
First-pass extracted concept
antioxidant therapies for COPD
Candidate: concept label1 source documents3 linked claims
Live refresh every 5sNext refresh in 5s
Evidence Snippets
Supporting Sources
Linked Claims
COPD progression and exacerbations are closely associated with tobacco smoke or biomass fuel-induced oxidative and aldehyde/carbonyl stress.
Quoted textsource-backed
The progression and exacerbations of chronic obstructive pulmonary disease (COPD) are intimately associated with tobacco smoke/biomass fuel-induced oxidative and aldehyde/carbonyl stress.
Named antioxidant agents in this review are reported to detoxify free radicals and oxidants, control expression of redox and glutathione biosynthesis genes, affect chromatin remodeling, and ultimately influence inflammatory gene expression.
Quoted textsource-backed
Various researches and clinical trials have revealed that these antioxidants can detoxify free radicals and oxidants, control expression of redox and glutathione biosynthesis genes, chromatin remodeling, and ultimately inflammatory gene expression.
Targeting systemic and local oxidative stress by modulating antioxidant or redox systems or boosting endogenous antioxidants is presented as a prudent therapeutic strategy for COPD treatment and management.
Quoted textsource-backed
it would be prudent to target systemic and local oxidative stress with agents that can modulate the antioxidants/ redox system or by boosting the endogenous levels of antioxidants for the treatment and management of COPD