First-pass extracted concept

antisense oligonucleotides

Candidate: concept label2 source documents3 linked claims

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Aliases

ASOs

Extracted Explainers

What the tool is doing

The review includes antisense oligonucleotides among the RNA-based therapeutic strategies assessed for multiple myeloma.

Source 1DOI PubMed

What problem it solves

They are presented as part of the effort to overcome resistance and improve treatment options in refractory disease.

Source 1DOI PubMed

Evidence Snippets

modalities including mRNA vaccines, small interfering RNAs (siRNAs), antisense oligonucleotides (ASOs), and microRNA (miRNA) mimics/inhibitors

Evidence 1Source 1DOI PubMedprovenance

the majority of approved OGTs, as well as those currently in clinical trials, are antisense oligonucleotides (ASOs) despite cell culture data showing that small interfering RNAs (siRNAs) exhibit greater potency.

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1primary paper2026MEDDOI PubMed

1 evidence snippet 2 linked claims Claim 1 Claim 2

Source 2primary paper2026MEDDOI PubMed

1 evidence snippet 1 linked claim Claim 1

Linked Claims

Claim 1modality comparisonsupports2026Source 2DOI PubMed

Most approved and clinical-trial oligonucleotide-based gene therapeutics are antisense oligonucleotides even though siRNAs show greater potency in cell culture data.

Quoted textsource-backed

the majority of approved OGTs, as well as those currently in clinical trials, are antisense oligonucleotides (ASOs) despite cell culture data showing that small interfering RNAs (siRNAs) exhibit greater potency.

Claim 2scope of reviewsupports2026Source 1DOI PubMed

The review assesses RNA-based therapeutic modalities for multiple myeloma including mRNA vaccines, siRNAs, ASOs, and miRNA mimics or inhibitors using preclinical and clinical evidence.

Quoted textsource-backed

In this review, we assess cutting-edge RNA-based therapeutics for MM modulation, drawing on preclinical and clinical evidence on modalities including mRNA vaccines, small interfering RNAs (siRNAs), antisense oligonucleotides (ASOs), and microRNA (miRNA) mimics/inhibitors.

Claim 3therapeutic potentialsupports2026Source 1DOI PubMed

The review concludes that RNA technologies have transformative potential in refractory multiple myeloma to achieve durable remissions, overcome resistance, reduce costs, and enable more personalized and safer treatments.

Quoted textsource-backed

By integrating these insights, we underscore RNA technologies' transformative potential to achieve durable remissions, overcome resistance, and reduce costs-paving the way for personalized, safer treatments in refractory MM.