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APOE4-associated neuronal hyperactivity phenotype

Candidate: concept label1 source documents4 linked claims
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Evidence Snippets

Here, we have identified an APOE4-associated hyperactivity phenotype in the brains of aged APOE mice
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1disease relevance hypothesissupports2017Source 1DOIPubMed

APOE4-driven hyperactivity may be a causative factor increasing Alzheimer's disease risk among APOE4 carriers.

Claim 2mechanistic explanationsupports2017Source 1DOIPubMed

The neuronal hyperactivity is driven by decreased background inhibition.

Claim 3phenotype associationsupports2017Source 1DOIPubMed

Aged APOE mice with APOE4 show an APOE4-associated neuronal hyperactivity phenotype.

Claim 4regional localizationsupports2017Source 1DOIPubMed

The most prominent APOE4-associated hyperactivity occurs in the entorhinal cortex.