it is necessary to assess the influence of the tested compounds on cellular processes such as the cell cycle, epithelial-mesenchymal transition, autophagy, and apoptosis.
First-pass extracted concept
apoptosis
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Evidence Snippets
Reactive Oxygen Species Across Death Pathways: Gatekeepers of Apoptosis, Ferroptosis, Pyroptosis, Paraptosis, and Beyond.
The supplied web research summary states that the 2018 NCCD recommendations explicitly cover intrinsic/extrinsic apoptosis.
This article describes our current knowledge of the role of NF-kappaB in apoptosis and necrosis.
Supporting Sources
Linked Claims
To develop effective anti-cancer therapy, the influence of tested compounds should be assessed on cell cycle, epithelial-mesenchymal transition, autophagy, and apoptosis.
Quoted textsource-backed
To develop effective anti-cancer therapy, it is essential to understand the processes regulating the progression and suppression of a given type of cancer. For this reason, it is necessary to assess the influence of the tested compounds on cellular processes such as the cell cycle, epithelial-mesenchymal transition, autophagy, and apoptosis.
This NCCD 2018 recommendations review covers multiple major cell-death modalities including apoptosis, MPT-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, and immunogenic cell death.
Quoted textsource-backed
Anchor article: the 2018 Nomenclature Committee on Cell Death (NCCD) recommendations is a broad consensus review that explicitly covers major regulated cell death modalities including intrinsic/extrinsic apoptosis, MPT-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, and immunogenic cell death.
NF-κB effects on apoptosis and necrosis vary markedly by cellular context and can include sensitization to death-inducing stimuli.
Quoted textsource-backed
its role in apoptosis and necrosis can vary markedly in different cell contexts, and NF-kappaB can sensitize cells to death-inducing stimuli in some instances
By 2006, substantial progress had been made in understanding NF-κB mechanisms in apoptosis and necrosis and in the regulation of its anti- versus proapoptotic activities.
Quoted textsource-backed
There has been substantial progress in understanding NF-kappaB's mode of action in apoptosis and necrosis and the mechanisms that regulate its anti- vs proapoptotic activities.
NF-κB transcription factors are major regulators of programmed cell death, including apoptosis and necrosis.
Quoted textsource-backed
The nuclear factor-kappaB (NF-kappaB) transcription factors have emerged as major regulators of programmed cell death (PCD) whether via apoptosis or necrosis.