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First-pass extracted concept

approaches to trigger and block astrocyte calcium signals

Candidate: concept label1 source documents4 linked claims
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Extracted Explainers

What the tool is doing

This concept covers methods used to induce or suppress astrocyte Ca2+ signals.

Source 1DOIPubMed

What problem it solves

It frames the causal-manipulation side of the review.

Source 1DOIPubMed

What it does not solve

The abstract does not identify the exact perturbation tools.

Source 1DOIPubMed

Evidence Snippets

the approaches used to broadly trigger and block Ca(2+) signals
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1causal inference requirementsupports2015Source 1DOIPubMed

Reliable methods to measure, mimic, and block specific astrocyte calcium signals with high temporal and spatial precision are needed to carefully test correlative and causative roles of these signals in astrocytes, blood vessels, neurons, and microcircuits.

Quoted textsource-backed
Once methods to reliably measure, mimic, and block specific astrocyte Ca(2+) signals with high temporal and spatial precision are available, researchers will be able to carefully explore the correlative and causative roles that Ca(2+) signals may play in the functions of astrocytes, blood vessels, neurons, and microcircuits in the healthy and diseased brain.
Claim 2methods needsupports2015Source 1DOIPubMed

Improved methods are needed to mimic and block molecularly defined types of astrocyte calcium signals within genetically specified astrocyte populations.

Quoted textsource-backed
Improved methods are also needed to mimic and block molecularly defined types of Ca(2+) signals within genetically specified populations of astrocytes.
Claim 3review scope summarysupports2015Source 1DOIPubMed

The review summarizes methods used to monitor astrocyte calcium signals, discovered signal classes, broad triggering and blocking approaches, and proposed or demonstrated physiological roles in neuronal microcircuits.

Quoted textsource-backed
We consider the methods that have been used to monitor astrocyte Ca(2+) signals, the various types of Ca(2+) signals that have been discovered (waves, microdomains, and intrinsic fluctuations), the approaches used to broadly trigger and block Ca(2+) signals, and, where possible, the proposed and demonstrated physiological roles for astrocyte Ca(2+) signals within neuronal microcircuits.
Claim 4study design recommendationsupports2015Source 1DOIPubMed

Studying astrocyte calcium activity in vivo is essential to distinguish pharmacological from physiological activity, and studying activity in situ is essential to rigorously explore mechanisms.

Quoted textsource-backed
Moreover, it will be essential to study astrocyte Ca(2+) activity in vivo to distinguish between pharmacological and physiological activity, and to study Ca(2+) activity in situ to rigorously explore mechanisms.