Sufficient evidence has been gathered in rodents to conclude that a subpopulation of arcuate kisspeptin neurons is, indeed, the GnRH pulse generator. Findings in other species are generally compatible with this view and suggest that arcuate/infundibular kisspeptin neurons represent the mammalian GnRH pulse generator.
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arcuate kisspeptin neurons
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arcuate/infundibular kisspeptin neurons
Evidence Snippets
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Findings in other species are generally compatible with the view that arcuate or infundibular kisspeptin neurons represent the mammalian GnRH pulse generator.
In rodents, a subpopulation of arcuate kisspeptin neurons is concluded to be the GnRH pulse generator.
Despite identifying the cells forming the pulse generator, the mechanisms of their synchronicity and the afferent hormonal and transmitter modulation establishing normal LH pulsatility remain largely unknown.
Available data support an extrinsic GnRH pulse generator located within the arcuate nucleus.
Past arcuate nucleus multiunit activity recordings were likely recordings from kisspeptin neurons.