First-pass extracted concept

arousal-action circuit

Candidate: concept label1 source documents4 linked claims

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Aliases

arousal-action circuit for sleep-wake control

Extracted Explainers

What the tool is doing

This is a proposed circuit framework for sleep-wake control. It separates wakefulness into arousal and action components and places REM and NREM sleep neurons within somatic and autonomic motor circuits.

Source 1DOI PubMed

What problem it solves

It addresses the poorly understood mechanism coordinating EEG, EMG, and autonomic changes during sleep-wake transitions.

Source 1DOI PubMed

What it does not solve

The abstract does not provide a concrete engineered tool, assay, or intervention that directly implements the model.

Source 1DOI PubMed

Alternatives

The abstract contrasts this proposal with less integrated views in which the coordinating circuit mechanism remains poorly understood.

Source 1DOI PubMed

Evidence Snippets

Here we propose an arousal-action circuit for sleep-wake control in which wakefulness is supported by separate arousal and action neurons, while REM and NREM sleep neurons are part of the central somatic and autonomic motor circuits.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2019Annual Review of NeuroscienceDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1conceptual modelsupports2019Source 1DOI PubMed

In the proposed model, REM and NREM sleep neurons are part of the central somatic and autonomic motor circuits.

Claim 2conceptual modelsupports2019Source 1DOI PubMed

The review proposes an arousal-action circuit model in which wakefulness is supported by separate arousal and action neurons.

Claim 3explanatory scopesupports2019Source 1DOI PubMed

The arousal-action circuit model can account for EEG, EMG, and autonomic profiles of wake, REM, and NREM states and several key features of their transitions.

Claim 4functional hypothesissupports2019Source 1DOI PubMed

The close association between sleep circuits and autonomic or somatic motor control circuits suggests that a primary function of sleep is to suppress motor activity.