First-pass extracted concept

arousal and sleep circuits

Candidate: concept label1 source documents4 linked claims

Jump to evidence Jump to sources Jump to claims

Live refresh every 5sNext refresh in 5s

Evidence Snippets

The principal neurons of the arousal and sleep circuits are comprised by glutamate and GABA neurons... regulate cortical activity and behavior across wake-sleep states.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1review2019NeuropsychopharmacologyDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1mechanistic summarysupports2019Source 1DOI PubMed

Both arousal and sleep circuit neurons are homeostatically regulated as a function of their activity in part through changes in receptors.

Claim 2review summarysupports2019Source 1DOI PubMed

Arousal and sleep circuits are principally composed of glutamate and GABA neurons distributed within the reticular core of the brain that regulate cortical activity and behavior across wake-sleep states through local and distant projections and interactions.

Claim 3review summarysupports2019Source 1DOI PubMed

Glutamate and GABA neurons in arousal and sleep circuits are heterogeneous in discharge profile and form distinct functional cell types that are maximally active during different wake, slow wave sleep, or REM sleep states.

Claim 4therapeutic summarysupports2019Source 1DOI PubMed

Major pharmacological agents used to treat wake and sleep disorders act on GABA and neuromodulatory transmission.