First-pass extracted concept

aryl hydrocarbon receptor

Candidate: concept label1 source documents5 linked claims

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Aliases

AHR

Evidence Snippets

The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor of the bHLH/PAS protein family.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2026MEDDOI PubMed

1 evidence snippet 5 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1disease associationsupports2026Source 1DOI PubMed

AHR is involved in cancer and autoimmune and inflammatory diseases and is a potential therapeutic target.

Claim 2functional rolesupports2026Source 1DOI PubMed

AHR is a ligand-dependent transcription factor in the bHLH/PAS protein family.

Claim 3ligand scopesupports2026Source 1DOI PubMed

AHR ligands include environmental toxins and microbial and dietary tryptophan metabolites, with context-dependent effects through canonical and noncanonical signaling.

Claim 4mechanistic scopesupports2026Source 1DOI PubMed

Recent structural studies have illuminated AHR ligand-binding mechanisms and regulation, informing its activation and transcriptional control.

Claim 5physiological rolesupports2026Source 1DOI PubMed

AHR functions as both a xenobiotic sensor and a central regulator of physiological homeostasis.