First-pass extracted concept

ASIC3

Candidate: concept label1 source documents3 linked claims

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Aliases

acid-sensing ion channel 3

Evidence Snippets

Here, we show that acid-sensing ion channel 3 (ASIC3) dramatically delays leukemogenesis.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1biological effectsupports2025Source 1DOI PubMed

ASIC3 delays leukemogenesis.

Claim 2genetic perturbation effectsupports2025Source 1DOI PubMed

Asic3 deletion enhances self-renewal, reduces differentiation, and increases murine acute myeloid LIC number by 9-fold.

Claim 3mechanistic claimsupports2025Source 1DOI PubMed

Acid-ASIC3 signaling inhibits murine and human LIC activities through a noncanonical mechanism involving interaction with the N-terminal of STIM1 and reduction of calcium-mediated CAMK1-CREB-MEIS1-LDHA levels without inducing cation currents.