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astrocyte calcium signaling

Candidate: concept label1 source documents4 linked claims
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Extracted Explainers

What the tool is doing

This concept covers intracellular Ca2+ activity in astrocytes and its proposed roles in microcircuits and blood-vessel interactions.

Source 1DOIPubMed

What problem it solves

It provides the organizing framework for comparing monitoring methods, signal classes, and perturbation approaches discussed in the review.

Source 1DOIPubMed

What it does not solve

It is not itself a tool or perturbation method.

Source 1DOIPubMed

Evidence Snippets

We provide an overview of recent progress on the study of astrocyte intracellular Ca(2+) signaling.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1causal inference requirementsupports2015Source 1DOIPubMed

Reliable methods to measure, mimic, and block specific astrocyte calcium signals with high temporal and spatial precision are needed to carefully test correlative and causative roles of these signals in astrocytes, blood vessels, neurons, and microcircuits.

Quoted textsource-backed
Once methods to reliably measure, mimic, and block specific astrocyte Ca(2+) signals with high temporal and spatial precision are available, researchers will be able to carefully explore the correlative and causative roles that Ca(2+) signals may play in the functions of astrocytes, blood vessels, neurons, and microcircuits in the healthy and diseased brain.
Claim 2methods gapsupports2015Source 1DOIPubMed

Further detailed work is needed to explore the biophysics and molecular mechanisms of calcium signaling throughout entire astrocytes, including fine distal extensions that interact with neurons and blood vessels.

Quoted textsource-backed
Although important progress has been made, we suggest that further detailed work is needed to explore the biophysics and molecular mechanisms of Ca(2+) signaling within entire astrocytes, including their fine distal extensions, such as processes that interact spatially with neurons and blood vessels.
Claim 3review scope summarysupports2015Source 1DOIPubMed

The review summarizes methods used to monitor astrocyte calcium signals, discovered signal classes, broad triggering and blocking approaches, and proposed or demonstrated physiological roles in neuronal microcircuits.

Quoted textsource-backed
We consider the methods that have been used to monitor astrocyte Ca(2+) signals, the various types of Ca(2+) signals that have been discovered (waves, microdomains, and intrinsic fluctuations), the approaches used to broadly trigger and block Ca(2+) signals, and, where possible, the proposed and demonstrated physiological roles for astrocyte Ca(2+) signals within neuronal microcircuits.
Claim 4study design recommendationsupports2015Source 1DOIPubMed

Studying astrocyte calcium activity in vivo is essential to distinguish pharmacological from physiological activity, and studying activity in situ is essential to rigorously explore mechanisms.

Quoted textsource-backed
Moreover, it will be essential to study astrocyte Ca(2+) activity in vivo to distinguish between pharmacological and physiological activity, and to study Ca(2+) activity in situ to rigorously explore mechanisms.