First-pass extracted concept

astrocyte-dependent adenosine A1 receptor signaling

Candidate: concept label1 source documents3 linked claims

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Evidence Snippets

astrocytic signaling to adenosine (A1) receptors was required for the robust reduction of depressive-like behaviors following 12 hours of sleep deprivation

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2013Translational PsychiatryDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1mechanistic insightsupports2013Source 1DOI PubMed

The study provides mechanistic insight that sleep deprivation impacts mood through glial signaling involving adenosine A1 receptors.

Claim 2mechanistic requirementsupports2013Source 1DOI PubMed

Astrocytic signaling to adenosine A1 receptors is required for the reduction of depressive-like behaviors following 12 hours of sleep deprivation.

Claim 3phenocopysupports2013Source 1DOI PubMed

Administration of the A1 agonist CCPA mimicked the effect of sleep deprivation on depression phenotypes.