Astrocyte-specific manipulation refers to approaches for selectively perturbing astrocytes to study their roles in circuits and behavior.
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astrocyte-specific manipulation
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Astrocytes regulate synapses, neuronal circuits, and behavior.
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Astrocytes are non-neuronal cells that regulate synapses, neuronal circuits, and behavior.
In vivo studies reviewed in this paper indicate that acute astrocyte manipulation with optogenetics or chemogenetics demonstrates a causal role for astrocytes in multiple behaviors and cognitive processes.
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Here we review recent findings on the active role of astrocytes in behavioral modulation with a focus on in vivo studies, primarily in mice. Using tools to acutely manipulate astrocytes, such as optogenetics or chemogenetics, studies reviewed here have demonstrated a causal role for astrocytes in sleep, memory, sensorimotor behaviors, feeding, fear, anxiety, and cognitive processes like attention and behavioral flexibility.
Current tools and future directions for astrocyte-specific manipulation include methods for probing astrocyte heterogeneity.
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Current tools and future directions for astrocyte-specific manipulation, including methods for probing astrocyte heterogeneity, are discussed.
At the tripartite synapse, astrocytes influence synapse formation, function, and plasticity.
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Astrocytes ensheath neuronal synapses to form the tripartite synapse where astrocytes influence synapse formation, function, and plasticity.