Central to this paradigm shift is the role of astrocytic Ca²⁺ signalling in modulating synaptic activity, plasticity, and network behaviour.
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astrocytic Ca2+ signalling
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Astrocytic Ca2+ waves are implicated in pathological states such as epilepsy.
Quoted textsource-backed
These discoveries extended to network-level phenomena, implicating astrocytic Ca2+ waves in pathological states like epilepsy.
Astrocytes actively participate in synaptic communication through Ca2+-dependent molecular signalling referred to as gliotransmission.
Quoted textsource-backed
Astrocytes, once considered passive support cells, have emerged as active participants in synaptic communication through Ca2+-dependent molecular signalling often referred to as gliotransmission.
Astrocytic Ca2+ signalling modulates synaptic activity, plasticity, and network behaviour.
Quoted textsource-backed
Central to this paradigm shift is the role of astrocytic Ca²⁺ signalling in modulating synaptic activity, plasticity, and network behaviour.
Intracellular Ca2+ fluctuations in astrocytes trigger release of signalling molecules that influence excitatory and inhibitory neuronal circuits.
Quoted textsource-backed
Carmignoto's research demonstrated that intracellular Ca2+ fluctuations in astrocytes trigger the release of signalling molecules, influencing both excitatory and inhibitory neuronal circuits.
Astrocytic dysfunction is related to epilepsy and dopaminergic dysregulation, suggesting therapeutic avenues through astrocyte-specific interventions.
Quoted textsource-backed
In the context of pathology, Carmignoto's studies related astrocytic dysfunction to epilepsy and dopaminergic dysregulation, suggesting new therapeutic avenues through astrocyte-specific interventions.