First-pass extracted concept

astroglial purinergic signaling

Candidate: concept label1 source documents3 linked claims

Jump to evidence Jump to sources Jump to claims

Live refresh every 5sNext refresh in 5s

Evidence Snippets

We found that astroglial purinergic signaling implements the inhibitory arm of this motif.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1conclusionsupports2025Source 1DOI PubMed

The study suggests an evolutionarily conserved astroglial purinergic signaling axis contributes to norepinephrine-mediated behavioral and brain state transitions.

Claim 2mechanismsupports2025Source 1DOI PubMed

Astroglial purinergic signaling implements the inhibitory arm of the norepinephrine-driven behavioral state transition motif.

Claim 3mechanismsupports2025Source 1DOI PubMed

In larval zebrafish, norepinephrine triggers astroglial ATP release, extracellular conversion of ATP into adenosine, and behavioral suppression through activation of hindbrain neuronal adenosine receptors.