Disrupted E/I coupling was associated with deficits in auditory-evoked gamma signal-to-noise ratio (SNR). ... These data demonstrate a clinically relevant, highly translatable neural-activity-based biomarker for preclinical screening and therapeutic development across a broad range of disorders that share common endophenotypes and disrupted NMDA-receptor signaling.
First-pass extracted concept
auditory-evoked gamma signal-to-noise ratio biomarker
Candidate: concept label1 source documents3 linked claims
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Aliases
auditory-evoked gamma SNR, gamma-SNR, neural-activity-based biomarker
Evidence Snippets
Supporting Sources
Linked Claims
Disrupted excitatory-inhibitory coupling is associated with deficits in auditory-evoked gamma signal-to-noise ratio.
Auditory-evoked gamma signal-to-noise ratio is presented as a clinically relevant, highly translatable neural-activity-based biomarker for preclinical screening and therapeutic development across disorders sharing disrupted NMDA-receptor signaling endophenotypes.
Gamma-band abnormalities predict deficits in spatial working memory and social preference in the NR1 hypofunction mouse model.