ASIA is presented as a syndrome concept that organizes evidence about environmental immune stimulatory factors under a common pathway of autoimmune pathogenesis.
First-pass extracted concept
Autoimmune/inflammatory syndrome induced by adjuvants
Candidate: concept label1 source documents5 linked claims
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Aliases
ASIA, Shoenfeld's syndrome
Extracted Explainers
Evidence Snippets
Supporting Sources
Linked Claims
The review states that recent cases support ASIA criteria by reporting symptom improvement after removal of adjuvants such as silicone breast implants.
Quoted textsource-backed
Recent cases will strengthen some of the criteria depicted in ASIA syndrome such as clear improvement of symptoms by the removal of adjuvants (e.g. silicone breast implants) from the body of patients.
The review proposes dysregulated autonomic GPCR autoantibodies and small fiber neuropathy as additional factors to include in ASIA criteria.
Quoted textsource-backed
Finally, we will introduce additional factors to be included in the criteria for ASIA syndrome such as: (1) dysregulated non-classical autoantibodies directed against G-protein coupled receptors (GPCRs) of the autonomic nervous system and (2)) small fiber neuropathy (SFN)
The review states that autoimmune symptoms can be triggered by exposure to environmental immune stimulatory factors acting as adjuvants in genetically susceptible individuals.
Quoted textsource-backed
During the past decades, evidence had been accumulating that (auto)immune symptoms can be triggered by exposure to environmental immune stimulatory factors that act as an adjuvant in genetically susceptible individuals.
The review identifies aluminum salts in vaccines, medical implants, and infectious agents as examples of environmental immune stimulators considered under ASIA.
Quoted textsource-backed
Such environmental immune stimulators, or adjuvants, include among others: aluminum salts as in vaccines, various medical implants, as well as various infectious agents.
ASIA was introduced as an umbrella syndrome to organize evidence that environmental immune stimulatory factors may share a common pathway of autoimmune pathogenesis.
Quoted textsource-backed
ASIA aimed to organize under a single umbrella, the existing evidence regarding certain environmental factors which possess immune stimulatory properties, in order to shed light on a common pathway of autoimmune pathogenesis.