First-pass extracted concept

autophagic flux

Candidate: concept label1 source documents6 linked claims

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Evidence Snippets

These center in particular around the accurate measurement of autophagic flux and its translation from the <i>in vitro</i> to the <i>in vivo</i> environment as well as its clinical application.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2019AutophagyDOI PubMed

1 evidence snippet 6 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1background biological rolesupports2019Source 1DOI PubMed

Macroautophagy is a critical intracellular bulk degradation system active at basal rates in eukaryotic cells.

Claim 2control strategysupports2019Source 1DOI PubMed

Inherent controls for autophagy analysis may help distinguish systemic and tissue-specific autophagic flux in future clinical applications.

Claim 3disease relevancesupports2019Source 1DOI PubMed

Autophagy is perturbed in many pathologies, and therapeutic enhancement or inhibition of this pathway has received considerable attention.

Claim 4measurement challengesupports2019Source 1DOI PubMed

Accurate measurement of autophagic flux and translation of those measurements from in vitro to in vivo settings remain unresolved challenges for clinical application.

Claim 5methodological alignmentsupports2019Source 1DOI PubMed

Techniques with desirable spatiotemporal resolution and multi-scale data collection are aligned with improving autophagic flux measurement in living organisms.

Claim 6standardization needsupports2019Source 1DOI PubMed

Current techniques may be used to establish autophagic flux standards or reference points.