The B cell antigen receptor (BCR) contains both Ig heavy and light chains and is expressed on immature and mature B cells before and after antigen encounter.
First-pass extracted concept
B cell antigen receptor
Candidate: concept label1 source documents5 linked claims
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Aliases
BCR
Evidence Snippets
Supporting Sources
Linked Claims
Engagement of BCR and preBCR rapidly activates receptor-proximal tyrosine kinases including Lyn, Blk, Syk, and Btk.
Quoted textsource-backed
Several protein tyrosine kinases are activated rapidly following engagement of the BCR/preBCR complexes, including members of the Src family (Lyn and Blk), the Syk/ZAP70 family (Syk), and the Tec family (Btk).
In immature B cells, BCR signaling responses include clonal anergy and apoptotic deletion.
Quoted textsource-backed
These responses include clonal anergy and apoptotic deletion in immature B cells
In mature B cells and preB cells, antigen receptor signaling responses include survival, proliferation, and differentiation.
Quoted textsource-backed
survival, proliferation, and differentiation in mature B and preB cells
Ig alpha and Ig beta link BCR and preBCR complexes to intracellular signal transduction pathways.
Quoted textsource-backed
Both receptor types from a complex with the Ig alpha and Ig beta proteins that link the predominantly extracellular Ig with intracellular signal transduction pathways.
BCR signaling induces different cellular responses depending on the nature of the signaling agent and the developmental stage of the target B-lineage cell.
Quoted textsource-backed
Signaling through the BCR induces different cellular responses depending on the nature of the signaling agent and the development stage of the target cell.