First-pass extracted concept

bacterial methylomes

Candidate: concept label1 source documents4 linked claims

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Aliases

methylomes

Evidence Snippets

This review traces the continuum from natural bacterial methylomes to engineered CRISPR-mediated epigenetic editing.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2025MEDDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1functional effectsupports2025Source 1DOI PubMed

Reversible epigenetic modifications can enable transient resistance, phenotypic heterogeneity, and biofilm persistence under antimicrobial stress without altering DNA sequence.

Claim 2measurement capabilitysupports2025Source 1DOI PubMed

Single-molecule sequencing and methylome mapping have uncovered diverse DNA methyltransferase systems that coordinate virulence, efflux, and stress responses.

Claim 3mechanistic rolesupports2025Source 1DOI PubMed

Epigenetic regulation, including DNA and RNA methylation, histone-like proteins, and small non-coding RNAs, plays a critical role in bacterial adaptability related to antibiotic resistance.

Claim 4multiomics integrationsupports2025Source 1DOI PubMed

Integrating methylomic data with transcriptomic and proteomic profiles reveals how epigenetic plasticity sustains antimicrobial tolerance across environments.