BphPs are bacterial photoreceptor scaffolds with NIR absorbance that can be repurposed into fluorescent probes. The review treats them as a major source lineage for NIR fluorescent proteins.
First-pass extracted concept
bacterial phytochrome photoreceptors
Candidate: concept label3 source documents5 linked claims
Live refresh every 5sNext refresh in 5s
Aliases
BphPs
Extracted Explainers
Evidence Snippets
Bacterial phytochrome photoreceptors (BphPs) ... possess the near-infrared (NIR) absorbance spectra that make them promising molecular templates to design NIR fluorescent proteins (FPs) and biosensors
Interestingly, natural Bacterial Phytochrome Photoreceptors (BphPs) utilize the low molecular weight biliverdin, found in most mammalian tissues, as a photoreactive chromophore. Due to their near-infrared absorbance BphPs are preferred templates for designing optical molecular tools for applications in mammals.
The paper reports bacteriophytochrome-derived photoactivatable near-infrared fluorescent proteins.
Supporting Sources
Linked Claims
The review compares phenotypes of current BphP-based near-infrared fluorescent proteins with fluorescent proteins derived from cyanobacteriochromes and allophycocyanins.
Bacterial phytochromes, some cyanobacteriochromes, and allophycocyanins are promising molecular templates for designing near-infrared fluorescent proteins and biosensors.
Bacterial phytochrome photoreceptors use biliverdin, a chromophore found in most mammalian tissues, which supports their use as templates for mammalian optical tools.
BphPs spectrally complement existing genetically encoded probes.
Because of their near-infrared absorbance, BphPs are preferred templates for designing optical molecular tools for applications in mammals.